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[SCI] ▶5년차◀ [국제] The antioxidant icariin protects porcine oocytes from age-related damage in vitro, 2020, ANIMAL BIOSCIENCE, 1-10.
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  • 작성일 2020-12-31 17:57:28
  • 조회수 1252

Treatment with 5 µM ICA (ICA-5) led to a significant reduction in ROS activity, but increased mRNA expression of glutathione and antioxidant genes (SOD1, SOD2, PRDX5, and NFE2L2), during aging in vitro. In addition, ICA-5 prevented defects in spindle formation and chromosomal alignment, and increased mRNA expression of cytoplasmic maturation factor genes (BMP15, CCNB1, MOS, and GDF9). It also prevented apoptosis, increased mRNA expression of anti-apoptotic genes (BCL2L1 and BIRC5), and reduced mRNA expression of pro-apoptotic genes (BAK1 and CASP3). Although the maturation and cleavage rates were similar in all groups, the total cell number per blastocyst and the percentage of apoptotic cells at the blastocyst stage were higher and lower, respectively, in the control and ICA-5 groups than in the aging group.


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